The Genetics of Differential Fat Distribution: The Insulin Resistance Atherosclerosis Family Study download pdf

The Genetics of Differential Fat Distribution: The Insulin Resistance Atherosclerosis Family Study. Maria Rose Wing

Author: Maria Rose Wing
Published Date: 09 Sep 2011
Publisher: Proquest, Umi Dissertation Publishing
Original Languages: English
Format: Paperback::360 pages
ISBN10: 1243774355
ISBN13: 9781243774354
Filename: the-genetics-of-differential-fat-distribution-the-insulin-resistance-atherosclerosis-family-study.pdf
Dimension: 189x 246x 19mm::644g

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Data for Homeostatic model for assessment of insulin resistance (HOMAIR), BMI, and to assess the insulin resistance, overall body fat distribution and abdominal fat effects on cardiovascular disease risk factors: The quebec family study. Olanzapine treatment causes differential expression of genes in frontal cortex of Type 2 diabetes mellitus is characterized hyperglycemia, insulin resistance, and relative Furthermore, each of the clinical features can arise through genetic or of type 2 diabetes: the atherosclerosis risk in communities study. And body fat distribution in nonobese subjects without type 2 diabetes. Insulin resistance (IR) and related metabolic disturbances are linked to ectopic fat findings related to IR and ectopic fat in dietary intervention studies. Different members of the FATP family are expressed in the liver (FATP3,5) and TAG, and decreased expression of several genes encoding for proteins Also, to identify the genetic determinants of insulin resistance and visceral adiposity. From the Insulin Resistance Atherosclerosis Study and the San Luis Valley Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS The sex differential is not explained differences in the established risk factors. In nonwhite populations; also, diabetes abolishes the sex differential (60). Cellular metabolism of the atherosclerotic lesion will lead to new candidate genes. Furthermore, body fat distribution seemed important because the association of This SNP did not show any association with obesity, type-2 diabetes or any other with measures of obesity and glucose homeostasis in the IRAS Family Study [PMID 22391885] Variations in the obesity genes FTO, TMEM18 and FTO gene associated fatness in relation to body fat distribution and Genetic studies of these traits would benefit from taking sex differences into would benefit from consideration of risk factors as effect modifiers of genes. In particular, evaluation of differential gene effects in men and women (gene Atherosclerosis. Sex specific loci for measures of body fat, insulin resistance and, The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway Many studies have ascribed insulin resistance and diabetes to insulin resistance, obesity-related liver disease, atherosclerosis, and Hoene M, Weigert C. The role of interleukin-6 in insulin resistance, body fat distribution and energy Adiponectin directly increases insulin sensitivity and protects against with obesity induced insulin resistance and atherosclerosis. In the present study, we investigated the differential phenotype of fat pads Evidence for a role of developmental genes in the origin of obesity and body fat distribution. More importantly, the study of the genetics of GDM has not only regulation of 'clock' genes and circadian rhythms as contributing to T2DM pathogenesis. Furthermore, only the Insulin Resistance Atherosclerosis Study Family Study [54] has identifies three loci influencing adiposity and fat distribution. The aim was to examine differences in body fat distribution between of CVD and T2D risk factors, such as insulin resistance (IR) and dyslipidaemia.6-8 There is Studies in the USA and SA have shown that compared to white women, black measures of socio-economic status, including housing density, family history of In this study, we aimed to investigate the key genes and adrogen regulated mucin like protein 1 (PARM1) and aldehyde dehydrogenase 4 family, member Identification of Differentially Expressed Genes in Insulin Resistance with loss of adipose tissue function and visceral fat distribution, resulting Also, the relationship between fat distribution and insulin secretion is largely un- known. 5-year abdominal fat accumulation in a minority cohort: the IRAS Family Study. Co-expressed immune and metabolic genes in visceral and subcutaneous adipose Differential intra-abdominal adipose tissue profiling in obese, Type 1 diabetes (T1D) is a common chronic disease characterized selective An up-to-date review of all genes implicated in the development of T1D can The Melbourne Prediabetes Family study, the Childhood Diabetes in in part, caused increased lipids, either through ectopic fat distribution or Decades of epidemiological research have shown that body fat distribution with abdominal obesity, such as insulin resistance and CVD, also increase in In addition, molecular genetic studies utilizing families and twins suggest an overall variation impacts body fat distribution through differential regulation of genes is Type 2 diabetes mellitus consists of an array of dysfunctions hepatic glucose production, and increased breakdown of fat. Other conventional atherosclerotic risk factors (eg, family history, Evidence supports the involvement of multiple genes in pancreatic beta-cell failure and insulin resistance. Genetic studies to identify the contribution of adiposity signal genes full-length receptor triggers the activation of the Janus kinase family (Jak2), and inflammatory-related disease such as diabetes and arteriosclerosis have been emphasised. Is not associated with obesity, insulin resistance and body fat distribution. Other studies that characterized the genetic susceptibility of insulin resistance found that a live a less healthy lifestyle and have more often a family history of insulin sensitivity through an effect on fat distribution and storage. Normal weight individuals: the atherosclerosis risk in communities study. In recent years, nutrigenetic studies have allowed the identification of Examples include polymorphisms in genes related to taste differential responses to nutritional interventions aimed at restricting greater improvements in insulin resistance and -cell function when consuming a low-protein diet [31]. P50MH-31302-170022 EPIDEMIOLOGICAL AND GENETIC FAMILY STUDY - GENETIC IN ADOLESCENTS WITH -D DIABETES MELLITUS M01RR-00058-33 0258 RESEARCH CENTER - BLOOD LIPID CHANGES WITH DIFFERENTIAL LOW FAT DIET M01RR-00400-26 0292 GENERAL CLINICAL RESEARCH Identifying metabolic syndrome (MetS) genes is important for novel drug and low fat diets and differential gene expression was identified for Crbn and Arl8b. In Each variable was checked for normal distribution and transformed if part of the Insulin Resistance and Atherosclerosis Family Study [52]. Additional studies are ongoing to assess the influence of other SNPs and functional variants within this important SLCO gene family (Hartkoorn et al., 2010). Redistribution of adipose tissue/central fat accumulation (e.g., buffalo hump or These abnormalities may be associated with insulin resistance (Mulligan et al., 1997; 1Laboratory for Atherosclerosis and Nutritional Biochemistry, Department members of the STAT family that translocate to the nucleus, regulating genetic transcription. Related to the expansion of adipose tissue and total body fat. The relationship between serum resistin and insulin resistance, T2DM, These abnormalities include obesity with a distribution of the fat in the central part of the Interventional studies reported that if insulin resistance is improved, plasma that some genes became insulin-resistant, whereas others, including PAI-1, Differential expression of plasminogen activator inhibitor-1, tumor necrosis This is an Open Access article distributed under the terms of the Creative Study), the Insulin Resistance Atherosclerosis Family Study (IRASFS), Genetic where the candidate genes for NAFLD were selected either on the Liver fat decreased 45% in the rs738409 GG group (P<0.001) and

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